OTUD5
Description
The OTUD5 (OTU deubiquitinase 5) is a protein-coding gene located on chromosome X.
OTUD5 is a deubiquitinating enzyme that negatively regulates the innate immune system by removing ubiquitin from TRAF3, thus suppressing type I interferon (IFN) production. It also acts as a positive regulator of mTORC1 and mTORC2 signaling by deubiquitinating BTRC, which promotes its stability and leads to mTORC1 and mTORC2 activation. OTUD5 can cleave various types of ubiquitin chains, including Lys-48-, Lys-63-, and Lys-11-linked chains, and plays a role in neuroectodermal differentiation by preventing the degradation of select chromatin regulators, such as ARID1A, HDAC2, and HCF1.
OTUD5 is also known as DUBA, MCAND.
