OTUD4
Description
The OTUD4 (OTU deubiquitinase 4) is a protein-coding gene located on chromosome 4.
OTUD4 is a protein encoded by the OTUD4 gene in humans. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells.
OTUD4 is a deubiquitinase that hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. It may negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, OTUD4 specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein, triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators. Independently of its catalytic activity, OTUD4 acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. It associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions.
OTUD4 is also known as DUBA6, HIN1, HSHIN1.
