OSGIN2
Osgin2 Gene: A Gateway to Understanding Complex Diseases
Description:
The osgin2 gene, located on chromosome 10q26.13, encodes a protein called Oxidative Stress-Induced Growth Inhibitor 2 (Osgin2). Osgin2 plays a crucial role in regulating cell growth, proliferation, and survival under oxidative stress conditions. It functions by inhibiting the activity of cyclin-dependent kinases (CDKs), which are essential for cell cycle progression.
Associated Diseases:
Mutations in the osgin2 gene have been linked to several diseases, including:
- Alzheimer's disease: Studies have shown that reduced Osgin2 expression is associated with increased accumulation of amyloid-beta plaques in the brain, a hallmark of Alzheimer's disease.
- Parkinson's disease: Osgin2 has been found to be downregulated in the substantia nigra of patients with Parkinson's disease, contributing to neuronal death and motor symptoms.
- Cancer: Osgin2 expression has been reported to be altered in various types of cancer, including lung cancer, breast cancer, and colorectal cancer. Its dysregulation can promote tumor growth and metastasis.
Did you Know ?
- Over 100 genetic variants within the osgin2 gene have been identified to be associated with increased risk of Alzheimer's disease.
