TNFAIP3

Description

TNFAIP3, also known as A20, is a crucial gene involved in the regulation of immune responses. It encodes a protein that acts as a negative regulator of NF-κB signaling pathway, a key pathway in inflammation and immunity. This gene‘s primary function is to prevent excessive inflammation by inhibiting the production of pro-inflammatory cytokines. TNFAIP3 plays a vital role in maintaining immune homeostasis and preventing autoimmune diseases.

Associated Diseases

• Autoimmune diseases like rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease
• Cancer, particularly lymphomas and multiple myeloma
• Inflammatory conditions such as Crohn‘s disease and ulcerative colitis
• Neurological disorders like Alzheimer‘s disease and Parkinson‘s disease

Did you know?

Mutations in the TNFAIP3 gene can lead to severe immune dysregulation and increased susceptibility to autoimmune diseases.