TLR7

Description

The TLR7 (toll like receptor 7) is a protein-coding gene located on chromosome X.

Toll-like receptor 7 (TLR7) is a protein encoded by the TLR7 gene in humans. It is a member of the toll-like receptor (TLR) family and detects single-stranded RNA (ssRNA), a common feature of viral genomes. TLR7 is predominantly expressed in the lung, placenta, and spleen. It recognizes ssRNA of viruses such as HIV and HCV, particularly those rich in guanine and uracil bases. TLR7 plays a crucial role in the immune response to viral infections and has been implicated in autoimmune disorders.

TLR7 is an endosomal receptor that plays a key role in innate and adaptive immunity. It controls the host immune response against pathogens by recognizing uridine-containing single-stranded RNAs (ssRNAs) of viral origin or guanosine analogs. Upon binding to agonists, TLR7 undergoes dimerization, bringing TIR domains from the two molecules into direct contact and leading to the recruitment of the TIR-containing downstream adapter MYD88 through homotypic interaction. This forms the Myddosome signaling complex, involving IRAK4, IRAK1, TRAF6, and TRAF3, which activates downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons.

TLR7 is also known as IMD74, SLEB17, TLR7-like.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing