STAT4
Description
The STAT4 gene (Signal Transducer and Activator of Transcription 4) plays a crucial role in the immune system by mediating the signaling pathways of various cytokines, primarily interferon-gamma (IFN-γ). This gene encodes a transcription factor that translocates to the nucleus upon activation and regulates the expression of target genes involved in immune cell differentiation, proliferation, and cytokine production. STAT4 is essential for the development and function of T helper 1 (Th1) cells, which are critical for cellular immunity against intracellular pathogens. It also contributes to the regulation of other immune cells, including natural killer (NK) cells and macrophages.
Associated Diseases
- Autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus)
- Inflammatory bowel disease (e.g., Crohn‘s disease, ulcerative colitis)
- Infections (e.g., tuberculosis, leishmaniasis)
- Cancer (e.g., lymphoma, leukemia)
Did you know?
STAT4 gene polymorphisms have been linked to an increased risk of developing certain autoimmune diseases, suggesting a role in disease susceptibility.
