PSTPIP1
Description
The PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1) is a protein-coding gene located on chromosome 15.
Proline-serine-threonine phosphatase-interacting protein 1 is an enzyme that in humans is encoded by the PSTPIP1 gene.
PSTPIP1 plays a crucial role in regulating the actin cytoskeleton, potentially influencing WAS actin-bundling activity. It acts as a bridge between ABL1 and PTPN18, promoting ABL1 dephosphorylation. PSTPIP1 might also serve as a scaffold protein for PTPN12 and WAS, enabling PTPN12 to dephosphorylate WAS. Additionally, it may connect CD2 and CD2AP to WAS, facilitating the recruitment of WAS to the T-cell:APC contact site and promoting actin polymerization required for synapse formation during T-cell activation. Furthermore, PSTPIP1 downregulates CD2-stimulated adhesion by coupling PTPN12 to CD2. It is also involved in innate immunity and the inflammatory response, being recruited to inflammasomes by MEFV. PSTPIP1 induces the formation of pyroptosomes, large supramolecular structures crucial for inflammatory apoptosis. This is achieved by binding to MEFV, enabling MEFV to bind to PYCARD and facilitating pyroptosome formation. Finally, PSTPIP1 regulates endocytosis and cell migration in neutrophils.
PSTPIP1 is also known as CD2BP1, CD2BP1L, CD2BP1S, H-PIP, PAPAS, PSTPIP.
