P4HA2
Description
The P4HA2 (prolyl 4-hydroxylase subunit alpha 2) is a protein-coding gene located on chromosome 5.
The P4HA2 gene in humans encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis. This enzyme is composed of two identical alpha subunits and two beta subunits. The protein encoded by P4HA2 is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. It catalyzes the formation of 4-hydroxyproline, essential for the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing of the P4HA2 gene produces transcript variants encoding different isoforms.
This enzyme catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences within collagens and other proteins.
P4HA2 is also known as MYP25, lncRNA-PE.
