MYH14
Description
The MYH14 (myosin heavy chain 14) is a protein-coding gene located on chromosome 19.
The MYH14 gene encodes a protein known as Myosin-14, which belongs to the myosin superfamily. Myosins are motor proteins that use actin as a track for movement, and they play diverse roles in cells, including cytokinesis (cell division), cell motility, and establishing cell polarity. Mutations in the MYH14 gene can lead to one form of autosomal dominant hearing impairment. This gene produces multiple transcript variants, resulting in different isoforms of the Myosin-14 protein.
MYH14 encodes a myosin protein involved in crucial cellular processes like cytokinesis (cell division), maintaining cell shape, and specialized functions including secretion and capping.
MYH14 is also known as DFNA4, DFNA4A, FP17425, MHC16, MYH17, NMHC II-C, NMHC-II-C, PNMHH, myosin.
Associated Diseases
- Deafness, autosomal dominant nonsyndromic sensorineural 4
- Peripheral neuropathy, myopathy, hoarseness, and hearing loss
- Peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome
