MUC1 : mucin 1, cell surface associated
Description
The MUC1 (mucin 1, cell surface associated) is a protein-coding gene located on chromosome 1.
The MUC1 gene provides instructions for making a protein called mucin 1, one of several mucin proteins that form mucus. Mucus lubricates and protects the lining of various body parts, including the airways, digestive system, and reproductive system. Mucin 1 extends through the cell membrane and is found in epithelial cells, primarily in the respiratory tract, female reproductive organs, and gastrointestinal tract. It has a mucin domain with repeated stretches of amino acids, modified by sugar chains. These sugars protect the cell surface and attract water, providing lubrication and hydration. The cytoplasmic tail of mucin 1, MUC1-CT, transmits signals from outside the cell to the nucleus, affecting cell growth, division, adhesion, movement, and survival. MUC1-CT may also relocate to the nucleus to influence gene activity. Mucin 1 is crucial for kidney development.
Mucin 1's alpha subunit can both promote and inhibit cell adhesion, contributing to cell-cell interactions. It also acts as a protective barrier against bacteria and enzymes, shielding epithelial cells from harm.
MUC1 is also known as ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM.
