KLRC4
Description
The KLRC4 (killer cell lectin like receptor C4) is a protein-coding gene located on chromosome 12.
KLRC4 encodes a type II integral membrane protein called NKG2-F, which is expressed primarily in natural killer (NK) cells. NK cells are lymphocytes that can kill tumor and virus-infected cells without prior activation. They also regulate the immune system. KLRC4 belongs to the NKG2 group of genes, which are characterized by a type II membrane orientation (extracellular C terminus) and a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region containing several C-type lectin genes specifically expressed on NK cells. The KLRC4 transcript's 3' end includes the first non-coding exon found at the 5' end of the adjacent D12S2489E gene transcript.
May play a role in recognizing MHC class I HLA-E molecules on NK cells.
KLRC4 is also known as NKG2-F, NKG2F.
