GPR101 : G protein-coupled receptor 101
Description
The GPR101 (G protein-coupled receptor 101) is a protein-coding gene located on chromosome X.
The GPR101 gene directs the production of a G protein-coupled receptor, a type of protein that sits within cell membranes and transmits signals from outside the cell to its interior. Although the specific role of the GPR101 protein remains unclear, it is primarily found in the brain, particularly the pituitary gland. This gland, located at the base of the brain, is responsible for releasing hormones that regulate critical bodily functions, including growth. GPR101's expression is particularly high during fetal development and adolescence, periods of significant growth, suggesting a possible role in the pituitary gland's cell growth or growth hormone release, or potentially both.
This receptor lacks a known ligand, meaning its specific function and the molecules it interacts with are currently unknown.
GPR101 is also known as GPCR6, PAGH2, PITA2.
Associated Diseases
- Chromosome Xq26.3 duplication syndrome
- Acromegaly
- Pituitary adenoma 2, GH-secreting
- X-linked acrogigantism
