F9 : coagulation factor IX
Description
The F9 (coagulation factor IX) is a protein-coding gene located on chromosome X.
The F9 gene provides instructions for producing coagulation factor IX, a crucial protein involved in blood clotting. This protein is made in the liver and circulates in the bloodstream in an inactive state. Upon injury to blood vessels, factor IX is activated by factor XIa, triggering a cascade of reactions leading to clot formation. This process seals off damaged vessels, preventing excessive blood loss.
Factor IX is a vitamin K-dependent plasma protein that plays a crucial role in the intrinsic pathway of blood coagulation. It activates factor X, transforming it into its active form. This activation process requires the presence of calcium ions (Ca(2+)), phospholipids, and activated factor VIII (factor VIIIa).
F9 is also known as F9 p22, FIX, HEMB, P19, PTC, THPH8.
