ACAN : aggrecan

---

Description

The ACAN gene provides instructions for making aggrecan, a crucial protein found in cartilage, the tough, flexible tissue that cushions joints. Aggrecan acts as a shock absorber, helping to prevent bones from rubbing against each other. It also plays a vital role in maintaining the structure and integrity of cartilage. Mutations in the ACAN gene can disrupt aggrecan production, leading to various health issues.

Associated Diseases

• Osteoarthritis
• Achondrogenesis
• Spondyloepiphyseal dysplasia
• Multiple epiphyseal dysplasia
• Schmid type metaphyseal chondrodysplasia

Did you know?

Aggrecan is a giant protein, one of the largest proteins found in the human body.