SLCO2A1
Description
The SLC02A1 gene encodes for the organic anion transporting polypeptide 1A1 (OATP1A1), a protein primarily expressed in the liver. OATP1A1 plays a crucial role in the uptake of various drugs, hormones, and bile acids into hepatocytes, influencing their metabolism and elimination. This protein is a member of the solute carrier (SLC) family, a vast group of membrane transporters that facilitate the movement of diverse substrates across cell membranes.
Associated Diseases
- **Genetic Variations and Drug Response:** Polymorphisms in the SLC02A1 gene have been linked to variations in drug response, leading to differences in drug efficacy and adverse effects. This is particularly relevant for drugs that are substrates of OATP1A1, such as statins, antibiotics, and anti-cancer agents.
- **Hepatic Diseases:** OATP1A1 dysfunction can contribute to the development of hepatic diseases like cholestasis, a condition characterized by impaired bile flow, and drug-induced liver injury (DILI). Mutations in the SLC02A1 gene can lead to impaired drug clearance, increasing the risk of DILI.
- **Neurological Disorders:** Some studies suggest that OATP1A1 may be involved in the transport of neurotransmitters and play a role in neurological disorders. However, further research is needed to clarify its specific function in the nervous system.
Did you know?
OATP1A1 is highly expressed in the liver, but it is also found in other tissues, including the brain, intestines, and kidneys, suggesting potential roles in various physiological processes.
