RNASEH2C : ribonuclease H2 subunit C
Description
The RNASEH2C (ribonuclease H2 subunit C) is a protein-coding gene located on chromosome 11.
The RNASEH2C gene provides instructions for making a subunit of the RNase H2 complex, a ribonuclease enzyme that breaks down RNA-containing molecules, particularly RNA-DNA hybrids. These hybrids are formed during DNA copying and are found in all cells. The RNase H2 complex is involved in DNA replication, error repair, and other cellular processes, including preventing inappropriate immune system activation.
RNASEH2C is a non-catalytic subunit of the RNase H2 complex, an endonuclease that specifically breaks down RNA in RNA:DNA hybrids. It plays a role in DNA replication, possibly by removing lagging-strand Okazaki fragment RNA primers during replication. It also helps remove single ribonucleotides from DNA:RNA duplexes.
RNASEH2C is also known as AGS3, AYP1.
