PRG4

Description

The PRG4 gene encodes a protein called lubricin, a major component of synovial fluid that plays a crucial role in joint lubrication and protection. Lubricin reduces friction between cartilage surfaces, allowing smooth joint movement and preventing wear and tear. It also possesses anti-inflammatory properties, contributing to joint health. Mutations in the PRG4 gene can lead to various joint disorders characterized by pain, stiffness, and reduced mobility.

Associated Diseases

• Osteoarthritis (OA)
• Chondrocalcinosis
• Rheumatoid arthritis (RA)
• Juvenile idiopathic arthritis (JIA)
• Camurati-Engelmann disease
• Pseudoxanthoma elasticum

Did you know?

Lubricin is one of the most slippery substances known, with a friction coefficient lower than ice on ice.