NGF : nerve growth factor
Description
Nerve growth factor (NGF) is a protein that plays a crucial role in the development, maintenance, and survival of neurons, particularly in the peripheral nervous system. It acts as a neurotrophic factor, promoting the growth, differentiation, and survival of neurons. NGF is synthesized and released by target cells, such as muscle cells, and binds to specific receptors on the surface of neurons, triggering intracellular signaling pathways that influence neuronal survival, growth, and function.
Associated Diseases
- Alzheimer‘s disease
- Parkinson‘s disease
- Huntington‘s disease
- Amyotrophic lateral sclerosis (ALS)
- Diabetic neuropathy
- Chronic pain conditions
Did you know?
NGF was the first neurotrophic factor discovered and the Nobel Prize in Physiology or Medicine was awarded to Rita Levi-Montalcini and Stanley Cohen in 1986 for their discovery of NGF.
