MMP2 : matrix metallopeptidase 2
Description
MMP2, also known as gelatinase A, is a zinc-dependent endopeptidase that plays a critical role in extracellular matrix (ECM) degradation. It belongs to the matrix metalloproteinase (MMP) family, a group of enzymes involved in tissue remodeling, wound healing, and various physiological and pathological processes. MMP2‘s primary function is to break down collagen, a major component of ECM, facilitating cell migration, angiogenesis, and tissue repair. However, MMP2‘s activity is tightly regulated, and its dysregulation can contribute to various diseases.
Associated Diseases
- Cancer (e.g., breast cancer, lung cancer, melanoma)
- Arthritis (e.g., osteoarthritis, rheumatoid arthritis)
- Cardiovascular diseases (e.g., atherosclerosis, aneurysm)
- Neurological disorders (e.g., Alzheimer‘s disease, stroke)
- Wound healing complications
Did you know?
MMP2 is activated by a unique mechanism involving the interaction with its pro-domain and TIMP-2 (tissue inhibitor of metalloproteinases-2). This activation process is crucial for maintaining the delicate balance between ECM degradation and tissue integrity.
