INPP5K
Description
INPP5K (Inositol Polyphosphate-5-Phosphatase K) is a crucial enzyme involved in the intricate cellular signaling pathways governed by phosphatidylinositol (PI) lipids. These lipids play critical roles in cellular processes, including membrane trafficking, cell growth, and signal transduction. INPP5K specifically hydrolyzes phosphatidylinositol 3,5-bisphosphate (PIP3,5P2) to phosphatidylinositol 3-phosphate (PIP3). This delicate balance between PIP3,5P2 and PIP3 is essential for fine-tuning downstream signaling events and maintaining cellular homeostasis.
Associated Diseases
- Neurodevelopmental disorders (e.g., intellectual disability, autism spectrum disorder)
- Cancer (e.g., leukemia, breast cancer)
- Immune system dysfunction (e.g., inflammatory bowel disease)
- Cardiovascular diseases
Did you know?
INPP5K has been implicated in the regulation of neuronal plasticity, a process crucial for learning and memory formation.
