IGKC
Description
The IGKC (immunoglobulin kappa constant) gene located on chromosome 2.
Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes the constant domain of kappa-type light chains for antibodies. It is found on chromosome 2, in humans, within the Immunoglobulin kappa locus, IGK@.
The IGKC gene encodes the constant domain of kappa-type light chains for antibodies. These light chains, along with heavy chains, form the antigen-binding sites of immunoglobulins (antibodies). Immunoglobulins are glycoproteins produced by B lymphocytes that play a crucial role in humoral immunity. Membrane-bound immunoglobulins act as receptors on B cells, triggering their activation and differentiation into antibody-secreting plasma cells upon antigen binding. Secreted immunoglobulins mediate the elimination of bound antigens, contributing to the effector phase of humoral immunity. The variable domains of heavy and light chains, assembled through V-(D)-J rearrangement and somatic hypermutation, provide the antigen-binding specificity and allow for affinity maturation during immune responses.
IGKC is also known as HCAK1, IGKCD, Km.
Associated Diseases
- Immunoglobulin kappa light chain deficiency
- Recurrent infections associated with rare immunoglobulin isotypes deficiency
