HPGD

Description

The HPGD gene, encoding the enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH), plays a crucial role in the metabolism of prostaglandins, lipid-derived signaling molecules involved in a wide range of physiological processes, including inflammation, pain, and blood pressure regulation. 15-PGDH catalyzes the inactivation of prostaglandins, converting them to inactive metabolites. This enzyme‘s activity is tightly regulated, ensuring a balanced response to prostaglandin signaling.

Associated Diseases

• Cancer (e.g., colorectal, breast, prostate)
• Cardiovascular disease
• Inflammatory bowel disease
• Pain syndromes
• Neurological disorders

Did you know?

Mutations in the HPGD gene have been associated with increased risk of certain types of cancer, suggesting that the enzyme‘s activity is a potential therapeutic target.