GP1BB : glycoprotein Ib platelet subunit beta
Description
The GP1BB (glycoprotein Ib platelet subunit beta) is a protein-coding gene located on chromosome 22.
The GP1BB gene provides instructions for making a protein called glycoprotein 1b-beta (GPIbβ). This protein is one subunit of a protein complex called GPIb-IX-V, which is essential for blood clotting. GPIb-IX-V is found on the surface of platelets, small cells that circulate in the blood and help form clots. The complex binds to von Willebrand factor (VWF), which is present on the inside surface of blood vessels, especially during injury. This binding allows platelets to adhere to the damaged blood vessel wall, initiating the formation of clots that seal the wound. To form the GPIb-IX-V complex, GPIbβ interacts with other subunits called GPIb-alpha, GPIX, and GPV, each produced by different genes. GPIbβ is crucial for assembling and stabilizing this complex on the platelet surface.
GP1BB, as part of the GPIb-IX-V complex, plays a crucial role in platelet plug formation by binding to von Willebrand factor (VWF) which is already attached to the subendothelium. This binding enables platelets to adhere to the damaged blood vessel wall, contributing to the clotting process and preventing excessive bleeding.
GP1BB is also known as BDPLT1, BS, CD42C, GPIBB, GPIbbeta.
