CD79B
Description
The CD79B (CD79b molecule) is a protein-coding gene located on chromosome 17.
CD79B, also known as CD79B (Cluster of Differentiation 79B), is a human gene associated with agammaglobulinemia-6. It encodes the Ig-beta protein, a crucial component of the B-cell antigen receptor complex. This complex also includes the antigen-specific surface immunoglobulin (Ig) and Ig-alpha. CD79B and Ig-alpha are necessary for the expression and function of the B-cell antigen receptor. Different isoforms of CD79B are produced through alternative splicing.
CD79B is essential for initiating the signal transduction cascade triggered by the B-cell antigen receptor complex (BCR) in cooperation with CD79A. This cascade leads to the internalization of the complex, its transport to late endosomes, and ultimately, antigen presentation. CD79B enhances the phosphorylation of CD79A, likely through recruitment of kinases that phosphorylate CD79A or by attracting proteins that bind to CD79A and safeguard it from dephosphorylation.
CD79B is also known as AGM6, B29, IGB, Igbeta.
