OR5A1
Description
The OR5A1 (olfactory receptor family 5 subfamily A member 1) is a protein-coding gene located on chromosome 11.
OR5A1 is a human gene encoding the olfactory receptor 5A1 protein. This protein participates in smell perception by interacting with odorant molecules in the nose. It triggers a neuronal response that leads to the sensation of smell. OR5A1 belongs to a large family of G-protein-coupled receptors (GPCRs), which are characterized by their 7-transmembrane domain structure. These receptors are responsible for recognizing and transmitting odorant signals via G proteins. The olfactory receptor gene family is the largest in the human genome. A genetic variation in OR5A1 (rs6591536) significantly affects the perception of beta-ionone, a compound responsible for floral scents. Individuals with at least one G allele are sensitive to beta-ionone and perceive it as a pleasant floral smell. However, those homozygous for the A allele are significantly less sensitive and perceive a pungent sour/vinegar odor at higher concentrations.
This protein acts as an odorant receptor, playing a role in detecting and recognizing specific smells.
OR5A1 is also known as OR11-249, OR5A1P, OST181.
