OR2AT4
Description
The OR2AT4 (olfactory receptor family 2 subfamily AT member 4) is a protein-coding gene located on chromosome 11.
OR2AT4 is an olfactory receptor that is activated by the synthetic sandalwood odorant sandalore. Its endogenous ligand is unknown. It is likely that OR2AT4's activity is mediated by G proteins which induce elevation of intracellular Ca(2+), a cAMP-dependent pathway, and phosphorylation of MAPK1/ERK2, MAPK3/ERK1, and p38 MAPKs. Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes. Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases. {ECO:0000269|PubMed:24999593, ECO:0000269|PubMed:30228264, ECO:0000305}
OR2AT4 is also known as OR11-265.
