OR1E2

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Description

The OR1E2 (olfactory receptor family 1 subfamily E member 2) is a protein-coding gene located on chromosome 17.

OR1E2 is a gene that encodes a protein called olfactory receptor 1E2. This protein is involved in the sense of smell. It interacts with odorant molecules in the nose, triggering a neuronal response that leads to the perception of a smell. OR1E2 is a member of a large family of G-protein-coupled receptors (GPCRs) that are responsible for detecting and transmitting odorant signals. The olfactory receptor gene family is the largest in the human genome.

Odorant receptor.

OR1E2 is also known as OR17-135, OR17-136, OR17-93, OR1E4, OR1E7, OST529.

Associated Diseases

• Lynch syndrome
• colorectal cancer, susceptibility to, 3
• Hirschsprung disease
• familial adenomatous polyposis 2
• AXIN2-related attenuated familial adenomatous polyposis
• 46,XY complete gonadal dysgenesis
• 46,XX ovotesticular disorder of sex development
• anal canal carcinoma
• hereditary mixed polyposis syndrome
• 46,XX testicular disorder of sex development
• familial visceral myopathy
• Lynch syndrome 8
• chronic intestinal pseudoobstruction
• testicular agenesis
• 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency
• Leydig cell hypoplasia
• colorectal cancer, susceptibility to, 10