ZNF143
Description
The ZNF143 (zinc finger protein 143) is a protein-coding gene located on chromosome 11.
Zinc finger protein 143 is a protein found in humans that is encoded by the ZNF143 gene. This protein is involved in a number of cellular processes, including gene regulation and transcription. Information about this protein is available from the U.S. National Library of Medicine and FactorBook.
ZNF143 is a transcriptional activator that plays a key role in regulating gene expression. It activates the gene for selenocysteine tRNA (tRNAsec), which is essential for the synthesis of selenoproteins. ZNF143 binds to the SPH motif of small nuclear RNA (snRNA) gene promoters, contributing to the efficient transcription of U6 RNA by RNA polymerase III. This process is facilitated by ZNF143‘s interaction with the CHD8 protein.
ZNF143 is also known as SBF, STAF, pHZ-1.
Associated Diseases
- methylmalonic aciduria and homocystinuria
- female infertility due to oocyte meiotic arrest
- male infertility with teratozoospermia due to single gene mutation
- female infertility due to zona pellucida defect
- spermatogenic failure 3
- spermatogenic failure 26
