TEAD1
Description
The TEAD1 (TEA domain transcription factor 1) is a protein-coding gene located on chromosome 11.
TEAD1, or TEA domain family member 1, is the first identified member of the TEAD family of transcription factors. TEAD proteins share a conserved DNA binding domain called the TEA domain, which recognizes the MCAT element (5’-CATTCCA/T-3’) sequence. The three-dimensional structure of the TEA domain, resembling the homeodomain, comprises three α helixes (H1, H2, and H3) with H3 being responsible for DNA binding. Another conserved domain at the C terminus enables TEAD1 to bind cofactors, such as YAP1. TEAD1 requires these cofactors to induce gene expression. TEAD1 is expressed in various tissues, including skeletal muscle, pancreas, placenta, lung, and heart.
TEAD1 plays a key role in the Hippo signaling pathway, which controls organ size and suppresses tumors by regulating cell growth and death. Within the Hippo pathway, TEAD1 acts as a downstream effector of YAP1 and TAZ, mediating their gene expression and regulating cell processes such as proliferation, migration, and epithelial-mesenchymal transition (EMT). TEAD1 binds specifically to the SPH and GT-IIC enhansons, activating transcription in a cell-specific manner, likely through interaction with a limiting cell-specific transcriptional intermediary factor (TIF). TEAD1 is involved in cardiac development and binds to the M-CAT motif.
TEAD1 is also known as AA, NTEF-1, REF1, TCF-13, TCF13, TEAD-1, TEF-1.
