SNRNP200
Description
The SNRNP200 (small nuclear ribonucleoprotein U5 subunit 200) is a protein-coding gene located on chromosome 2.
SNRNP200 gene encodes for U5 small nuclear ribonucleoprotein 200 kDa helicase, an enzyme involved in the splicing of pre-mRNA. It is a core component of spliceosomal complexes, participating in the assembly, activation, and disassembly of the spliceosome.
SNRNP200, also known as Activating signal cointegrator 1 complex subunit 3-like 1, BRR2 homolog, U5 snRNP-specific 200 kDa protein, is a crucial enzyme involved in pre-mRNA splicing. It acts as a helicase, catalyzing the ATP-dependent unwinding of U4/U6 RNA duplexes, a vital step in forming a catalytically active spliceosome. SNRNP200 plays a central role in pre-mRNA splicing, acting as a core component of various spliceosomal complexes, including those involved in pre-catalytic, catalytic, and post-catalytic stages. Furthermore, SNRNP200 is likely involved in splicing of U12-type introns in pre-mRNAs as part of the minor spliceosome. It participates in spliceosome assembly, activation, and disassembly, mediating changes in the intricate network of RNA-RNA interactions within the spliceosome.
SNRNP200 is also known as ASCC3L1, BRR2, HELIC2, RP33, U5-200KD.
