OVOL2
Description
The OVOL2 (ovo like zinc finger 2) is a protein-coding gene located on chromosome 20.
OVOL2 is a zinc-finger transcription repressor factor that plays a crucial role in regulating various cellular processes. It suppresses epithelial-to-mesenchymal transition (EMT) by repressing the expression of ZEB1, a key EMT inducer. OVOL2 promotes neuronal differentiation and inhibits cell cycling and terminal differentiation of keratinocytes by directly repressing the expression of MYC and NOTCH1. This protein is also essential for the proper development of primordial germ cells in embryos. OVOL2 plays a dual role in thermogenesis and adipogenesis, promoting brown/beige adipose tissue-mediated thermogenesis and inhibiting adipogenesis in white adipose tissues. It interacts with and inhibits the transcription factor activity of CEBPA, a key regulator of adipogenesis.
OVOL2 is also known as CHED, CHED1, CHED2, EUROIMAGE566589, PPCD1, ZNF339.
