NR2F1
Description
The NR2F1 (nuclear receptor subfamily 2 group F member 1) is a protein-coding gene located on chromosome 5.
COUP-TF1 (COUP Transcription Factor 1), also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1), is a protein encoded by the NR2F1 gene in humans. It belongs to the nuclear hormone receptor family of steroid hormone receptors. COUP-TF1 binds to the ovalbumin promoter and, in conjunction with another protein (S300-II), stimulates the initiation of transcription. It binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. COUP-TF1 interacts with proteins like BCL11A, BCL11B, COPS2, and ESR1. Mutations in the NR2F1 gene have been associated with Bosch-Boonstra-Schaaf optic atrophy syndrome.
COUP-TF1 binds to the ovalbumin promoter and, in conjunction with another protein (S300-II), stimulates the initiation of transcription. It binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. COUP-TF1 represses the transcriptional activity of LHCG.
NR2F1 is also known as BBOAS, BBSOAS, COUP-TFI, COUPTF1, EAR-3, EAR3, ERBAL3, SVP44, TCFCOUP1, TFCOUP1.
