KIF11

Description

The KIF11 (kinesin family member 11) is a protein-coding gene located on chromosome 10.

KIF11 is a molecular motor protein essential for mitosis. It belongs to the kinesin superfamily, which are nanomotors that move along microtubule tracks in the cell. KIF11 is also known as Kinesin-5, BimC, Eg5, or N-2. There are over 70 different eukaryotic kinesin-5 proteins identified. This protein family is involved in spindle dynamics and mitosis. KIF11 is involved in chromosome positioning, centrosome separation, and establishing a bipolar spindle during mitosis. Its role in mitosis and potential as a therapeutic target for cancer have been actively studied. KIF11 is a homotetramer that cross-links anti-parallel microtubules in the mitotic spindle, maintaining spindle bipolarity. The motor domain is located at the N-terminus, responsible for ATP hydrolysis and microtubule binding.

KIF11 is also known as EG5, HKSP, KNSL1, MCLMR, TRIP5.

Associated Diseases

• Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation
• Microcephaly-lymphedema-chorioretinopathy syndrome