CHRDL1
Description
The CHRDL1 (chordin like 1) is a protein-coding gene located on chromosome X.
Chordin-like 1 (CHRDL1) is a protein encoded by the CHRDL1 gene on the X chromosome. It is a structural glycoprotein that specifically encodes Venotropin, an antagonist of bone morphogenetic protein 4 (BMP4). CHRDL1 plays a crucial role in embryonic cell differentiation, osteogenesis, neurogenesis, tumor and metastasis suppression, and retinal formation. It is highly expressed in the anterior eye segment and retina, as well as in the cerebellum and neocortex. In the neocortex, its expression peaks during synapse maturation, highlighting its importance in proper central nervous system and eye development. Mutations in CHRDL1 are associated with Neuhäuser Syndrome, X-linked megalocornea, and central corneal thickness.
CHRDL1 is also known as CHL, MGC1, MGCN, NRLN1, VOPT, dA141H5.1.
