CHMP4B
Description
The CHMP4B (charged multivesicular body protein 4B) is a protein-coding gene located on chromosome 20.
CHMP4B is a protein encoded by the CHMP4B gene in humans. It is a core component of the ESCRT-III complex involved in the formation of multivesicular bodies (MVBs), which are responsible for the sorting and degradation of cellular components.
CHMP4B is a core component of the ESCRT-III complex, which plays a crucial role in the formation of multivesicular bodies (MVBs). MVBs are essential for sorting and degrading various cellular components, including membrane proteins, lysosomal enzymes, and lipids. The process involves the invagination and scission of the endosomal membrane to form intraluminal vesicles (ILVs). ESCRT-III proteins, including CHMP4B, are thought to mediate this membrane fission event, potentially in conjunction with the VPS4 ATPase. CHMP4B also contributes to other cellular processes, such as the terminal stages of cytokinesis, nuclear envelope sealing, and mitotic spindle disassembly. Furthermore, CHMP4B is involved in the exosomal release of specific proteins, including SDCBP, CD63, and syndecan. The majority of CHMP4B exists in a folded, closed conformation.
CHMP4B is also known as C20orf178, CHMP4A, CTPP3, CTRCT31, SNF7, SNF7-2, Shax1, VPS32B, Vps32-2, dJ553F4.4.
