BMP7

Description

The BMP7 (bone morphogenetic protein 7) is a protein-coding gene located on chromosome 20.

Bone morphogenetic protein 7 or BMP7 (also known as osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the BMP7 gene. The protein encoded by this gene is a member of the TGF-β superfamily. Like other members of the bone morphogenetic protein family of proteins, it plays a key role in the transformation of mesenchymal cells into bone and cartilage. It is inhibited by noggin and a similar protein, chordin, which are expressed in the Spemann-Mangold Organizer. BMP7 may be involved in bone homeostasis. It is expressed in the brain, kidneys and bladder. BMP7 induces the phosphorylation of SMAD1 and SMAD5, which in turn induce transcription of numerous osteogenic genes. It has been demonstrated that BMP7 treatment is sufficient to induce all of the genetic markers of osteoblast differentiation in many cell types. The role of BMP7 in mammalian kidney development is through induction of MET of the metanephrogenic blastema. The epithelial tissue emerging from this MET process eventually forms the tubules and glomeruli of the nephron.

BMP7 is a growth factor belonging to the TGF-beta superfamily that plays a crucial role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis, and skeletal morphogenesis. It activates the canonical BMP signaling cascade by binding to type I receptor ACVR1 and type II receptor ACVR2A. Upon binding, ACVR2A phosphorylates and activates ACVR1, which in turn phosphorylates SMAD1/5/8. These activated SMAD proteins translocate to the nucleus where they regulate transcription of target genes. BMP7 can also signal through non-canonical pathways, such as the P38 MAP kinase signaling cascade, which promotes brown adipocyte differentiation through the activation of target genes, including members of the SOX family of transcription factors. BMP7 promotes the expression of HAMP, a process that is inhibited by its interaction with ERFE.

BMP7 is also known as OP-1.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing