ABCB6
Description
The ABCb6 gene, also known as ATP-binding cassette sub-family B member 6, plays a crucial role in cellular transport, specifically the movement of molecules across cell membranes. This gene encodes a protein that acts as a transporter, facilitating the passage of various substrates, including steroids, drugs, and toxins. ABCb6 is widely expressed in different tissues, including the brain, liver, and kidneys, highlighting its significant role in maintaining cellular homeostasis and overall physiological function.
Associated Diseases
- Neurological disorders: Mutations in ABCb6 have been linked to neurodevelopmental disorders and epilepsy.
- Cancer: ABCb6 overexpression has been observed in certain cancers, suggesting its involvement in tumor growth and resistance to chemotherapy.
- Steroid-related disorders: ABCb6 plays a role in steroid hormone transport and metabolism, and its dysregulation may contribute to steroid-related diseases.
Did you know?
ABCb6 is an example of a ‘drug efflux pump,‘ which can remove drugs from cells, potentially contributing to drug resistance.
