RARB
Description
The Retinoic Acid Receptor Beta (RARB) gene plays a crucial role in regulating cellular differentiation, growth, and development. It encodes a nuclear receptor protein that binds to retinoic acid, a derivative of vitamin A, triggering a cascade of gene expression changes that ultimately dictate cell fate. This gene‘s activity is essential for the proper development of various organs and tissues, particularly in the nervous system, hematopoietic system, and skin. Mutations or dysregulation of the RARB gene can disrupt these processes, leading to various developmental and pathological conditions.
Associated Diseases
- Acute Promyelocytic Leukemia (APL)
- Retinoid Embryopathy
- Other cancers (e.g., breast cancer, lung cancer)
- Neurodevelopmental disorders
- Skin disorders
Did you know?
The RARB gene‘s discovery was instrumental in the development of targeted therapies for acute promyelocytic leukemia, a type of cancer where RARB is often disrupted.
