PROP1 : PROP paired-like homeobox 1
Description
The PROP1 (PROP paired-like homeobox 1) is a protein-coding gene located on chromosome 5.
The PROP1 gene provides instructions for producing a transcription factor protein that regulates the activity of other genes. This protein is exclusively found in the pituitary gland, a crucial organ at the base of the brain that secretes hormones vital for growth, reproduction, and other essential bodily functions. The PROP1 protein plays a role in the specialization of different cell types within the pituitary gland.
The PROP1 protein likely plays a role in the development of pituitary gonadotropes, somatotropes, lactotropes, and caudomedial thyrotropes.
PROP1 is also known as CPHD2, PROP-1.
Associated Diseases
- Non-acquired panhypopituitarism
- Pituitary hormone deficiency, combined, 2
- Hypothyroidism due to deficient transcription factors involved in pituitary development or function
- Combined pituitary hormone deficiencies, genetic forms
- Combined pituitary hormone deficiency
