GRIP1 : glutamate receptor interacting protein 1
Description
The GRIP1 (glutamate receptor interacting protein 1) is a protein-coding gene located on chromosome 12.
The GRIP1 gene provides instructions for making a protein that binds to other proteins and plays a crucial role in directing their movement within cells. For instance, it targets FRAS1 and FREM2 proteins to specific regions of the cell, allowing them to form the FRAS/FREM complex, which is found in basement membranes that support and separate cells in various tissues. This complex is vital during development before birth, anchoring the top layer of skin and contributing to the development of organs like the kidneys. GRIP1 also targets proteins to synapses in the brain, where communication between nerve cells takes place. GRIP1 may also play a role in the development of neurons.
GRIP1 acts as a scaffold for the assembly of multiprotein signaling complexes within neurons. It also facilitates the movement of its interacting partners to specific locations within cells. This protein forms a complex with NSG1, GRIA2, and STX12, influencing the fate of AMPAR receptors and directing the GRIA2 subunit toward recycling and membrane targeting.
GRIP1 is also known as FRASRS3, GRIP.
