GPR179
Description
The GPR179 (G protein-coupled receptor 179) is a protein-coding gene located on chromosome 17.
GPR179, also known as Probable G-protein coupled receptor 179, is a protein encoded by the GPR179 gene in humans. Mutations in this gene have been associated with cases of congenital stationary Night Blindness.
GPR179 is an orphan receptor involved in vision, specifically required for signal transduction through retinal depolarizing bipolar cells. It acts as an atypical G-protein coupled receptor, recruiting and regulating R7 group RGS-GNB5 complexes instead of activating G proteins. This unique mechanism promotes the GTPase activator activity of R7 RGS proteins, increasing the GTPase activity of G protein alpha subunits and driving them into their inactive GDP-bound form. GPR179 associates with components of the metabotropic signaling cascade in retina ON-bipolar neurons, such as TRPM1 and GRM6, potentially controlling the ability of the GRM6 cascade to gate TRPM1.
GPR179 is also known as CSNB1E, GPR158L, GPR158L1.
