CRB1 : crumbs cell polarity complex component 1
Description
The CRB1 (crumbs cell polarity complex component 1) is a protein-coding gene located on chromosome 1.
The CRB1 gene provides instructions for making a protein that is crucial for normal vision. This protein is found in the brain and the retina, where it helps in the development of light-sensing cells called photoreceptors. The CRB1 protein is part of a group of proteins that control the structure and orientation of photoreceptors. It may also be involved in creating connections between different cell types in the retina.
The CRB1 protein is involved in the development and structure of photoreceptor cells in the retina, which are essential for vision. It may also contribute to maintaining cell polarization and adhesion.
CRB1 is also known as CRB1-A, CRB1-B, CRB1-C, LCA8, RP12.
Associated Diseases
- Leber congenital amaurosis
- Retinitis pigmentosa 12
- Leber congenital amaurosis 8
- Pigmented paravenous chorioretinal atrophy
- Nanophthalmos
- Retinitis pigmentosa
- Cone-rod dystrophy
