AGK
Description
The AGK (acylglycerol kinase) is a protein-coding gene located on chromosome 7.
AGK refers to Acylglycerol kinase, mitochondrial (hAGK), also known as Multiple substrate lipid kinase. It is a lipid kinase involved in mitochondrial function and cell signaling.
AGK is a lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. It does not phosphorylate sphingosine but can phosphorylate ceramide. AGK preferentially phosphorylates 1,2-dioleoylglycerol over 2,3-dioleoylglycerol. AGK is also a component of the TIM22 complex, which is involved in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex uses the membrane potential as its driving force and is essential for the import of certain metabolite carriers like ANT1/SLC25A4 and SLC25A24, but not for the import of TIMM23. Overexpression of AGK leads to increased formation and secretion of LPA, which activates the EGFR and downstream MAPK signaling pathway, ultimately promoting cell growth.
AGK is also known as CATC5, CTRCT38, MTDPS10, MULK.
Associated Diseases
- Congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome
- Cataract, autosomal recessive congenital 5
- Sengers syndrome
