OOEP

Description

The OOEP (oocyte expressed protein) is a protein-coding gene located on chromosome 6.

OOEP is a protein involved in various cellular processes, particularly in oocyte and early embryonic development. It is a component of the subcortical maternal complex (SCMC), a protein complex that plays a crucial role in the early stages of embryonic development. OOEP is also involved in DNA repair and replication, and it plays a role in the regulation of actin dynamics.

OOEP, in collaboration with KHDC3L, acts as a scaffold, attracting BLM and TRIM25 to DNA replication forks. This interaction triggers the ubiquitination of BLM by TRIM25, enhancing its retention at replication forks. This process, in turn, facilitates the restart of stalled replication forks. OOEP positively regulates the repair of DNA double-strand breaks (DSBs) via homologous recombination by influencing ATM activation and RAD51 recruitment to DSBs within oocytes. This activity contributes to oocyte survival and the successful completion of meiosis. As a component of the subcortical maternal complex (SCMC), OOEP plays a vital role in enabling zygotes to progress beyond the first embryonic cell divisions by regulating actin dynamics. Specifically, OOEP is essential for the formation of F-actin cytoplasmic lattices in oocytes. These lattices are responsible for the symmetric division of zygotes through the regulation of mitotic spindle formation and positioning.

OOEP is also known as C6orf156, FLOPED, HOEP19, KHDC2.

Associated Diseases

WES Whole Exome Sequencing