OIP5

Description

The OIP5 (Opa interacting protein 5) is a protein-coding gene located on chromosome 15.

In telecommunications, a third-order intercept point (IP3 or TOI) is a specific figure of merit associated with the more general third-order intermodulation distortion (IMD3), which is a measure for weakly nonlinear systems and devices, for example receivers, linear amplifiers and mixers. It is based on the idea that the device nonlinearity can be modeled using a low-order polynomial, derived by means of Taylor series expansion. The third-order intercept point relates nonlinear products caused by the third-order nonlinear term to the linearly amplified signal, in contrast to the second-order intercept point that uses second-order terms. The intercept point is a purely mathematical concept and does not correspond to a practically occurring physical power level. In many cases, it lies far beyond the damage threshold of the device.

== Definitions == Two different definitions for intercept points are in use:

Based on harmonics: The device is tested using a single input tone. The nonlinear products caused by n-th-order nonlinearity appear at n times the frequency of the input tone. Based on intermodulation products: The device is fed with two sine tones one at

      f
      
        1
      
    
  

{displaystyle f_{1}}

and one at

      f
      
        2
      
    
  

{displaystyle f_{2}}

. When you cube the sum of these sine waves you will get sine waves at various frequencies including

    (
    2
    
      f
      
        2
      
    
    −
    
      f
      
        1
      
    
    )
  

{displaystyle (2f_{2}-f_{1})}

and

    (
    2
    
      f
      
        1
      
    
    −
    
      f
      
        2
      
    
    )
  

{displaystyle (2f_{1}-f_{2})}

. If

      f
      
        1
      
    
  

{displaystyle f_{1}}

and

      f
      
        2
      
    
  

{displaystyle f_{2}}

are large but very close together then

    (
    2
    
      f
      
        2
      
    
    −
    
      f
      
        1
      
    
    )
  

{displaystyle (2f_{2}-f_{1})}

and

    (
    2
    
      f
      
        1
      
    
    −
    
      f
      
        2
      
    
    )
  

{displaystyle (2f_{1}-f_{2})}

will be very close to

      f
      
        1
      
    
  

{displaystyle f_{1}}

and

      f
      
        2
      
    
  

{displaystyle f_{2}}

OIP5 is essential for the recruitment of CENPA to centromeres, which is crucial for proper chromosome segregation during cell division (mitosis).

OIP5 is also known as 5730547N13Rik, CT86, LINT-25, MIS18B, MIS18beta, hMIS18beta.

Associated Diseases

WES Whole Exome Sequencing