OGG1
Description
The OGG1 (8-oxoguanine DNA glycosylase) is a protein-coding gene located on chromosome 3.
OGG1, also known as 8-Oxoguanine glycosylase, is a DNA glycosylase enzyme encoded by the OGG1 gene. It plays a crucial role in base excision repair, a DNA repair pathway that removes damaged or modified bases from DNA. OGG1 specifically removes 8-oxoguanine (8-oxoG), a mutagenic base byproduct that arises from exposure to reactive oxygen species (ROS). It can both cleave the glycosidic bond of the damaged base and introduce a break in the DNA backbone. Alternative splicing of the OGG1 gene generates different variants, classified as type 1 and type 2, depending on the terminal exon. All variants share the same N-terminal region, and while many splice variants have been identified, the complete structure of each variant is not fully determined.
OGG1 is also known as HMMH, HOGG1, MUTM, OGH1.
