OGFR
Description
The OGFR (opioid growth factor receptor) is a protein-coding gene located on chromosome 20.
The Opioid growth factor receptor, also known as OGFr or the ζ-opioid receptor, is a protein encoded by the OGFR gene in humans. It binds to opioid growth factor (OGF), also known as [Met(5)]-enkephalin, a known opioid peptide. Although originally discovered as a new opioid receptor zeta (ζ), it shares little sequence similarity with other opioid receptors and has distinct functions. Its primary function appears to be in regulating tissue growth, playing a role in embryonic development, wound repair, and certain cancers. OGF acts as a negative regulator of cell proliferation and tissue organization. The receptor, when unbound to OGF, resides on the outer nuclear envelope and translocates to the nucleus upon binding OGF. The gene contains a polymorphic region with 60 nt tandem imperfect repeat units, resulting in transcripts with varying numbers of repeats (zero to eight). The receptor is composed of a chain of 677 amino acids, including a nuclear localization sequence region.
OGFR is also known as -.
