NXF1
Description
The NXF1 (nuclear RNA export factor 1) is a protein-coding gene located on chromosome 11.
Nuclear RNA export factor 1, also known as NXF1 or TAP, is a protein which in humans is encoded by the NXF1 gene.
== Function == This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. Alternative splicing results in transcript variants. The LRRs and NTF2-like domains are required for export activity. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. A variant allele of the homologous Nxf1 gene in mice suppresses a class of mutations caused by integration of an endogenous retrovirus (intracisternal A particle) into an intron.
== Interactions == NXF1 has been shown to interact with TNPO2, MAGOH, U2 small nuclear RNA auxiliary factor 1, DHX9, HuD and NUP214.
== Tap protein == In molecular biology, another name for the protein NXF1 is TAP. In particular this entry focuses on the C-terminal domain, which also contains the UBA (protein domain).
NXF1, also known as TAP, plays a critical role in exporting mRNA from the nucleus to the cytoplasm. This includes transporting mRNAs containing retroviral constitutive transport elements (CTEs) and participating in the TAP/NFX1 pathway. NXF1 forms a heterodimer with NXT1, which is involved in exporting HSP70 mRNA alongside ALYREF/THOC4 and THOC5 components of the TREX complex. It is believed that ALYREF/THOC4-bound mRNA is transferred to the NXF1-NXT1 heterodimer for export. NXF1 is also involved in the nuclear export of mRNAs containing m6A modifications. The interaction of SRSF3 and YTHDC1 facilitates the binding of m6A-containing mRNA to both SRSF3 and NXF1, promoting mRNA nuclear export.
NXF1 is also known as MEX67, TAP.
