NUF2
Description
The NUF2 (NUF2 component of NDC80 kinetochore complex) is a protein-coding gene located on chromosome 1.
The NUF2 gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. This complex plays a crucial role in chromosome segregation, particularly during meiosis, where it regulates the separation of chromosomes. The human NUF2 protein is also found associated with centromeres in mitotic cells, indicating its role in chromosome segregation during mitosis. Alternatively spliced transcript variants of the NUF2 gene have been described, but these variants encode the same protein.
NUF2, also known as CDCA1, is a key component of the NDC80 complex, which is crucial for proper chromosome segregation during cell division. This complex ensures accurate chromosome separation by facilitating spindle checkpoint activity and maintaining kinetochore integrity. The NDC80 complex also plays a role in organizing stable microtubule binding sites at the kinetochore, which are essential for microtubule attachment and chromosome movement. Furthermore, the NDC80 complex works in synergy with the SKA1 complex to enhance microtubule affinity, enabling the NDC80 complex to track depolymerizing microtubules, contributing to the dynamic regulation of microtubule interactions during cell division.
NUF2 is also known as CDCA1, CT106, NUF2R.
