NSFL1C
Description
The NSFL1C (NSFL1 cofactor) is a protein-coding gene located on chromosome 20.
NSFL1 cofactor p47, encoded by the NSFL1C gene, is a protein involved in membrane fusion processes. It works in conjunction with two ATPases: N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97). A trimer of NSFL1C binds to a hexamer of p97, playing a crucial role in the reassembly of Golgi cisternae from mitotic Golgi fragments. The gene produces multiple transcript variants, leading to the creation of different isoforms. NSFL1C has been shown to interact with valosin-containing protein.
NSFL1C reduces the ATPase activity of VCP. It is required for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. NSFL1C may also play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). NSFL1C inhibits the activity of CTSL. Together with UBXN2B/p37, it regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. It also regulates spindle orientation during mitosis.
NSFL1C is also known as P47, UBX1, UBXD10, UBXN2C, dJ776F14.1.
